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J Antimicrob Chemother. 2000 Nov;46(5):827-30.

In vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia.

Author information

1
Service de Microbiologie, Hôpital Louis Mourier, 92701 Colombes, France.

Abstract

We evaluated the in vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia using a susceptible strain and one with low-level resistance (MIC/MBC of levofloxacin: 0.06/0.06 and 4/4 mg/L, respectively). As demonstrated previously with other pathogens, the AUC/MIC ratio predicted the efficacy of fluoroquinolones against A. baumannii. This parameter correlated with bactericidal effect and survival. Combination therapy did not enhance the efficacy of levofloxacin.

PMID:
11062208
DOI:
10.1093/jac/46.5.827
[Indexed for MEDLINE]

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