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J Antimicrob Chemother. 2000 Nov;46(5):807-10.

Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii.

Author information

1
Institute of Infectious Diseases and Public Health, University of Ancona, c/o Azienda Ospedaliera Umberto I, Piazza Cappelli 1, Ancona, Italy. cmalinf@popsci.unian.it

Abstract

The in vitro activity of buforin II, cecropin P1, indolicidin, magainin II and ranalexin, alone and in combination with eight clinically used antimicrobial agents was investigated against 12 multidrug-resistant strains of Acinetobacter baumannii isolated from immunocompromised patients. Antimicrobial activities were measured by MIC, MBC and viable count. The peptides had a varied range of inhibitory values: overall, the organisms were more susceptible to buforin II (MIC range 0.25-16 mg/L), cecropin P1 (0.50-32 mg/L) and magainin II (0.50-16 mg/L). Synergy occurred when magainin II was combined with beta-lactam antibiotics.

PMID:
11062203
DOI:
10.1093/jac/46.5.807
[Indexed for MEDLINE]

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