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J Clin Microbiol. 2000 Nov;38(11):4228-32.

Detection of extended-spectrum beta-lactamases in klebsiellae with the Oxoid combination disk method.

Author information

1
Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom.

Abstract

The Oxoid combination disk method for detecting extended-spectrum beta-lactamases (ESBLs) depends on comparing the inhibition zones of cefpodoxime (10-microg) and cefpodoxime-plus-clavulanate (10- plus 1-microg) disks. The presence of clavulanate enlarged the zones for all of 180 ESBL-producing klebsiellae by >/=5 mm, whereas zones for cefpodoxime-susceptible isolates and cefpodoxime-resistant isolates with AmpC and K1 beta-lactamases were enlarged by </=1 mm. Good discrimination was achieved with either the NCCLS or the British disk method.

PMID:
11060096
PMCID:
PMC87569
[Indexed for MEDLINE]
Free PMC Article

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