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Biochim Biophys Acta. 2000 Oct 18;1482(1-2):9-24.

The lipocalin protein family: structural and sequence overview.

Author information

1
The Edward Jenner Institute for Vaccine Research, Newbury, Berkshire, UK. darren.flower@jenner.ac.uk

Abstract

Lipocalins are remarkably diverse at the sequence level yet have highly conserved structures. Most lipocalins share three characteristic conserved sequence motifs - the kernel lipocalins - while others are more divergent family members - the outlier lipocalins - typically sharing only one or two. This classification is a useful tool for analysing the family, and within these large sets are smaller groups sharing much higher levels of sequence similarity. The lipocalins are also part of a larger protein superfamily: the calycins, which includes the fatty acid binding proteins, avidins, a group of metalloproteinase inhibitors, and triabin. The superfamily is characterised by a similar structure (a repeated +1 topology beta-barrel) and by the conservation of a remarkable structural signature.

PMID:
11058743
DOI:
10.1016/s0167-4838(00)00148-5
[Indexed for MEDLINE]

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