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Crit Care. 2000;4(3):188-92. Epub 2000 Apr 13.

Helium-oxygen mixture does not improve gas exchange in mechanically ventilated children with bronchiolitis.

Author information

1
Children's Hospital Health Center, San Diego, California, USA.

Abstract

STATEMENT OF FINDINGS:

Varying concentrations of helium-oxygen (heliox) mixtures were evaluated in mechanically ventilated children with bronchiolitis. We hypothesized that, with an increase in the helium:oxygen ratio, and therefore a decrease in gas density, ventilation and oxygenation would improve in children with bronchiolitis. Ten patients, aged 1-9 months, were mechanically ventilated in synchronized intermittent mandatory ventilation (SIMV) mode with the following gas mixtures delivered at 15-min intervals: 50%/50% nitrogen/oxygen, 50%/50% heliox, 60%/40% heliox, 70%/30% heliox, and return to 50%/50% nitrogen/oxygen. The use of different heliox mixtures compared with 50%/50% nitrogen/oxygen in mechanically ventilated children with bronchiolitis did not result in a significant or noticeable decrease in ventilation or oxygenation.

PMID:
11056751
PMCID:
PMC29042
DOI:
10.1186/cc692
[Indexed for MEDLINE]
Free PMC Article

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