Format

Send to

Choose Destination
Crit Care. 1999;3(1):11-16.

Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis.

Author information

1
Department of Surgery, Veterans Affairs Medical Center and George Washington University Medical Center, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA. jcwhite1@erols.com

Abstract

BACKGROUND:

Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia.

RESULTS:

Incremental increases in doses of bacteria resulted in proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml). Gel filtration studies revealed that ProCT was the predominant (> 90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium.

CONCLUSIONS:

In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels.

PMID:
11056717
PMCID:
PMC29007
DOI:
10.1186/cc300

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center