Format

Send to

Choose Destination
Arthritis Res. 2000;2(4):327-36. Epub 2000 Jun 8.

Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells.

Author information

1
Department of Oncology/Haematology, University Hospital Charité (Campus Mitte), Berlin, Germany. oliver.rosen@rz.hu-berlin.de

Abstract

Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondritis and systemic lupus erythematosus (SLE), even at advanced stage, with the use of autologous stem-cell transplantation (SCT). Remissions persisted after reconstitution of the immune system. In the treatment of advanced systemic sclerosis (SSc), stable disease may be achieved with autologous SCT.

PMID:
11056673
PMCID:
PMC17815
DOI:
10.1186/ar107
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center