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Nat Cell Biol. 2000 Nov;2(11):E207-9.

Conformational disease.

Author information

1
Department of Biological Sciences, Stanford University, Stanford, California 94305-5020, USA. kopito@leland.stanford.edu

Abstract

A large and diverse number of diseases are now recognized as 'conformational diseases', caused by adoption of non-native protein conformations that lead to aggregation. The recent conference, 'Alpha1-antitrypsin deficiency and other conformational diseases', held in Airlie, Virginia, USA (27-30 June, 2000) focused on some of the common pathways by which cells protect themselves from toxicity associated with protein misfolding and aggregation.

PMID:
11056553
DOI:
10.1038/35041139
[Indexed for MEDLINE]

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