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Nat Cell Biol. 2000 Nov;2(11):792-6.

Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis.

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1
[1] Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

Abstract

Coliform bacteria detect chemical attractants by means of a membrane-associated cluster of receptors and signalling molecules. We have used recently determined molecular structures, in conjunction with plastic models generated by three-dimensional printer technology, to predict how the proteins of the complex are arranged in relation to the plasma membrane. The proposed structure is a regular two-dimensional lattice in which the cytoplasmic ends of chemotactic-receptor dimers are inserted into a hexagonal array of CheA and CheW molecules. This structure creates separate compartments for adaptation and downstream signalling, and indicates a possible basis for the spread of activity within the cluster.

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PMID:
11056533
DOI:
10.1038/35041030
[Indexed for MEDLINE]

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