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Nucl Med Biol. 2000 Aug;27(6):627-30.

Column-switching HPLC for the analysis of plasma in PET imaging studies.

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1
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. jhilton@jhmi.edu

Abstract

A column-switch high performance liquid chromatography method for the analysis of 4 mL of plasma is described with six examples of chromatography of [(11)C]-labeled positron-emission tomography imaging agents. Complete extraction of all but the most polar metabolites by the reverse phase capture column is achieved by disruption of plasma protein binding by 8 M urea.

PMID:
11056380
[Indexed for MEDLINE]
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