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Curr Opin Hematol. 2000 Nov;7(6):414-9.

Laboratory diagnosis of autoimmune cytopenias.

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Blood Bank and Transfusion Medicine Department, Hadassah Medical Organization, Kiryat Hadassah, Jerusalem, Israel.


The past year's literature shows that little progress has been achieved in the laboratory diagnosis of autoimmune hemolytic anemia. The direct antiglobulin test is the only diagnostic test for autoimmune hemolytic anemia. Advantages of new techniques, such as the gel test, have to be determined. Today, cephalosporins are known to cause both drug-dependent and -independent autoantibodies. The diagnosis of idiopathic thrombocytopenic purpura is a clinical one. The new assays that measure antibodies against specific glycoproteins offer improved specificity. New laboratory advancements and accumulation of data on granulocytes' antigens and antibodies enabled us to recommend guidelines for the laboratory investigation of autoimmune neutropenia.

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