Format

Send to

Choose Destination
Neuron. 2000 Sep;27(3):539-50.

Actin-dependent regulation of neurotransmitter release at central synapses.

Author information

1
Division of Biology, University of California, San Diego, La Jolla 92093, USA.

Abstract

Depolymerization of actin by latrunculin A transiently promotes neurotransmitter release. The mean rate of mEPSCs increases by a Ca2+-independent process, without a concomitant change in the mean amplitude. The readily releasable vesicle pool size and the rate of refilling of the readily releasable pool remain unaltered by latrunculin treatment. Evoked neurotransmitter release also increases in a manner consistent with an increase in vesicle release probability. The observed enhancement of neurotransmitter release is specific to actin depolymerization mediated by latrunculin A and is not caused by cytochalasin D. Our findings indicate that actin participates in a regulatory mechanism that restrains fusion of synaptic vesicles at the active zone.

PMID:
11055436
DOI:
10.1016/s0896-6273(00)00064-7
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center