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Bioorg Med Chem Lett. 2000 Oct 16;10(20):2263-6.

Analogues of SB-203207 as inhibitors of tRNA synthetases.

Author information

1
Research School of Chemistry, Australian National University, Canberra, ACT. easton@rsc.anu.edu.au

Abstract

SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and valine increased the potency of inhibition of LRS and VRS, respectively. The leucine derivative showed low level antibacterial activity, while several of the compounds inhibited IRS from Staphylococcus aureus WCUH29 more strongly than rat liver IRS.

PMID:
11055334
DOI:
10.1016/s0960-894x(00)00456-x
[Indexed for MEDLINE]

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