Format

Send to

Choose Destination
Trends Neurosci. 2000 Oct;23(10 Suppl):S8-19.

Pathophysiology of the basal ganglia in Parkinson's disease.

Author information

1
Dept of Neurology, Neuroscience Centre, Clinica Universitaria and Medical School, University of Navarra, Pamplona, Spain.

Abstract

Insight into the organization of the basal ganglia in the normal, parkinsonian and L-dopa-induced dyskinesia states is critical for the development of newer and more effective therapies for Parkinson's disease. We believe that the basal ganglia can no longer be thought of as a unidirectional linear system that transfers information based solely on a firing-rate code. Rather, we propose that the basal ganglia is a highly organized network, with operational characteristics that simulate a non-linear dynamic system.

PMID:
11052215
DOI:
10.1016/s1471-1931(00)00028-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center