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Curr Opin Microbiol. 2000 Oct;3(5):451-8.

Signature-tagged mutagenesis in the identification of virulence genes in pathogens.

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Microscience Ltd, 545 Eskdale Road, Winnersh Triangle, RG41 5TU, Wokingham, Berkshire, UK.


Signature-tagged mutagenesis is a functional genomics technique that identifies microbial genes required for infection within an animal host, or within host cells. The application of this technique to a range of microbial pathogens has resulted in the identification of novel virulence determinants in each screen performed to date, so that cumulatively several hundred genes have been ascribed a role in virulence.

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