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Trends Biochem Sci. 2000 Oct;25(10):496-502.

STAT proteins and transcriptional responses to extracellular signals.

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Immunobiology Center, Box 1630, East Building Room 12-20D, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.


Signal transducer and activator of transcription (STAT) transcription factors are implicated in programming gene expression in biological events as diverse as embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation in organisms ranging from slime molds to insects to man. Rapid progress has unearthed much about the activation of STATs by Janus kinases (JAKs) and other tyrosine kinases and their ability to interface with other signaling systems. Once inside the nucleus, the STATs bind to promoters and join other transcriptional activators in the regulation of gene expression.

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