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Trends Biochem Sci. 2000 Oct;25(10):469-74.

BRCA1: exploring the links to transcription.

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1
Dept of Cell Biology, Weill Medical College of Cornell University, New York, NY 10021, USA.

Abstract

Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.

PMID:
11050427
[Indexed for MEDLINE]
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