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Curr Biol. 2000 Oct 5;10(19):R704-7.

Cooperativity: action at a distance in a classic system.

Author information

1
Department of Biological Sciences, State University of New York at Buffalo, Cooke Hall, North Campus, Buffalo, New York 14260-1300, USA. koudelka@acsu.buffalo.edu

Abstract

A new high resolution crystal structure of the phage lambda repressor reveals the basis for repressor dimer formation and, together with biochemical data, provides insights into the mechanism of repressor tetramer formation, a process essential to the cooperative binding and gene regulatory activities of this protein.

PMID:
11050405
DOI:
10.1016/s0960-9822(00)00710-7
[Indexed for MEDLINE]
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