Send to

Choose Destination
Biol Trace Elem Res. 2000 Sep;76(3):193-205.

Zinc status and immune system relationship: a review.

Author information

Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.


The essentiality of zinc for humans was first documented by Prasad in the 1960s. The main clinical manifestations associated with zinc deficiency are growth retardation, hypogonadism, diarrhea, and increased susceptibility to infectious diseases. Thus, in the past 25 yr, there was an increased interest of researchers in studying the role of zinc in human immunity. Although mechanistic research has been carried out using animal models, there are several studies in humans with similar results. This work is an attempt to review the information available in this field to understand the important role that zinc plays in the normal development and function of the immune system.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center