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Int J Med Microbiol. 2000 May;290(2):175-81.

Genetic variability within Helicobacter pylori.

Author information

1
Institut für Hygiene und Mikrobiologie der Universität Würzburg, Germany. ssuer-baum@hygiene.uni-wuerzburg.de

Abstract

One of the striking characteristics of the human gastric pathogen Helicobacter pylori is extensive genetic diversity between different strains. During the last years, intensive research using genomic, molecular genetic and population genetic approaches has permitted to quantitate the diversity in H. pylori, to define its characteristics, and to understand the mechanisms that generate diversity in this global pathogen. This review summarizes the recent developments in this rapidly moving field and discusses the significance of genomic heterogeneity and nucleotide sequence diversity in the contexts of H. pylori epidemiology and pathogenesis.

PMID:
11045922
DOI:
10.1016/S1438-4221(00)80087-9
[Indexed for MEDLINE]

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