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Trends Microbiol. 2000 Oct;8(10):452-6.

The Toll receptor family and microbial recognition.

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  • 1Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.


The survival of multicellular organisms is dependent on their ability to recognize invading microbial pathogens and to induce a variety of defense reactions. Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses.

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