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Biochem Soc Trans. 2000 Oct;28(5):536-40.

The polymorphic telomeres of the African Trypanosome trypanosoma brucei.

Author information

  • 1Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, UK. gloria.rudenko@ceid.ox.ac.uk

Abstract

African trypanosomes have plastic genomes with extensive variability at the chromosome ends. The genes encoding the expressed major surface protein of the infective bloodstream form stages of Trypanosoma brucei and are located at telomeres. These telomeric expression-site transcription units are turning out to be surprisingly polymorphic in structure and sequence.

PMID:
11044370
PMCID:
PMC3375589
[PubMed - indexed for MEDLINE]
Free PMC Article
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