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Curr Opin Struct Biol. 2000 Oct;10(5):518-27.

Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans.

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Kobe Pharmaceutical University, Department of Biochemistry, Higashinada-ku, 658-8558, Kobe, Japan.


Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering long-standing questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are crucial to the expression and regulation of the biological functions of glycosaminoglycans in development and pathophysiology.

[Indexed for MEDLINE]

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