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Curr Opin Struct Biol. 2000 Oct;10(5):510-7.

Glycosyltransferase structure and mechanism.

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Departments of Molecular and Medical Genetics and Biochemistry, University of Toronto, Ontario, M5S 1A8, Toronto, Canada.


The high-resolution X-ray crystal structures of a new form of bacteriophage T4 beta-glucosyltransferase, Escherichia coli MurG, Bacillus subtilis SpsA, bovine beta-1,4-galactosyltransferase 1 and rabbit N-acetylglucosaminyltransferase I have now been solved. These glycosyltransferase structures have provided the first detailed view of the structural basis of catalysis, as well as new insight into glycosyltransferase classification.

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