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Semin Radiat Oncol. 2000 Oct;10(4):296-307.

The physical parameters and molecular events associated with radiation-induced lung toxicity.

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Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.


Radiation therapy (RT) is frequently used to treat patients with tumors in and around the thorax. Clinical radiation pneumonitis is a common side effect, occurring in 5% to 20% of patients. Efforts to identify patients at risk for pneumonitis have focused on physical factors, such as dose and volume. Recently, the underlying molecular biological mechanisms behind RT-induced lung injury have come under study. Improved knowledge of the molecular events associated with RT-induced lung injury may translate into a better ability to individualized therapy. This review discusses our current understanding of the physical and molecular factors contributing to RT-induced pulmonary injury.

[Indexed for MEDLINE]

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