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Semin Radiat Oncol. 2000 Oct;10(4):296-307.

The physical parameters and molecular events associated with radiation-induced lung toxicity.

Author information

1
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. vujaskovic@radonc.duke.edu

Abstract

Radiation therapy (RT) is frequently used to treat patients with tumors in and around the thorax. Clinical radiation pneumonitis is a common side effect, occurring in 5% to 20% of patients. Efforts to identify patients at risk for pneumonitis have focused on physical factors, such as dose and volume. Recently, the underlying molecular biological mechanisms behind RT-induced lung injury have come under study. Improved knowledge of the molecular events associated with RT-induced lung injury may translate into a better ability to individualized therapy. This review discusses our current understanding of the physical and molecular factors contributing to RT-induced pulmonary injury.

PMID:
11040330
[Indexed for MEDLINE]

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