Format

Send to

Choose Destination
Eur J Hum Genet. 2000 Oct;8(10):805-8.

A reinvestigation of non-disjunction resulting in 47, XXY males of paternal origin.

Author information

1
Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wiltshire, UK. wessex.genetics@dial.pipex.com

Abstract

We have used polymorphisms within the Xp/Yp pseudoautosomal region (PAR 1) to determine the frequency and location of recombination in 80 paternally derived 47, XXY males. Of 64 informative results, there were 10 single cross-overs, one double cross-over and 53 without a cross-over. Therefore 2/3 of 47, XXY males of paternal origin result from meiosis in which the X and Y chromosomes fail to recombine. This failure was not associated with the presence of an increase in recombination in the smaller Xq/Yq pseudoautosomal region (PAR 2) or with the presence of microdeletions within PAR 1.

PMID:
11039584
DOI:
10.1038/sj.ejhg.5200531
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center