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Chemistry. 2000 Sep 15;6(18):3321-9.

Maximizing synthetic efficiency: multi-component transformations lead the way

Author information

1
Rhone-Poulenc Industrialisation, St-Fons, France. hugues.bienayme@crit.rhone-poulenc.com

Abstract

With the emergence of high-throughput screening in the pharmaceutical industry in the early 1990's, organic chemists were faced with a new challenge: how to prepare large collections of molecules (the libraries) to "feed" the high-throughput screen? The unique exploratory power of some reactions (such as the 40 year-old Ugi four-component condensation) was soon recognized to be extremely valuable to produce libraries in a time- and cost-effective manner. Over the last five years, industrial and academic researchers have made these powerful transformations into one of the most efficient and cost-effective tools for combinatorial and parallel synthesis.

PMID:
11039522

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