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J Paediatr Child Health. 2000 Oct;36(5):449-52.

Hepatic glycogenosis: reversible hepatomegaly in type 1 diabetes.

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Department of Endocrinology, Royal Children's Hospital, Herston, Queensland, Australia.



To describe the aetiology, clinical features and appropriate treatment for hepatic glycogenosis in poorly controlled type 1 diabetes.


A review of three adolescents with poor diabetes control, hepatomegaly and elevated serum liver transaminase concentrations.


Symptoms included abdominal pain, anorexia, nausea and vomiting. All had tender hepatomegaly; two had splenomegaly. Liver biopsy was performed on two patients. Histology revealed hepatic glycogenosis in both; one also demonstrated macrovesicular steatosis. With improved glycaemic control, all three showed resolution of their symptoms, organomegaly and elevated serum liver transaminase concentrations.


Insulin-reversible hepatic glycogenosis is the most common cause of hepatomegaly and raised serum liver transaminase concentrations in children and adolescents with type 1 diabetes. Having excluded other causes of hepatic dysfunction, a 4 week therapeutic trial of improved glycaemic control is recommended prior to more invasive investigations.

[Indexed for MEDLINE]

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