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Twin Res. 2000 Sep;3(3):129-33.

Infant zygosity can be assigned by parental report questionnaire data.

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  • 1Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK.


A parental report questionnaire posted to a population sample of 18-month-old twins correctly assigned zygosity in 95%of cases when validated against zygosity determined by identity of polymorphic DNA markers. The questionnaire was as accurate when readministered at 3 years of age, with 96% of children being assigned the same zygosity on both occasions. The results validate the use of parental report questionnaire data to determine zygosity in infancy.

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