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FEBS Lett. 2000 Oct 13;483(1):6-10.

Regulation of APP cleavage by alpha-, beta- and gamma-secretases.

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1
Laboratory of Molecular Neurobiology, Department of Pathology, University of Melbourne, 3010, Melbourne, Vic., Australia.

Abstract

Proteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by APP secretases is a key event in Alzheimer's disease (AD) pathogenesis. alpha-Secretases cleave APP within the amyloid sequences, whereas beta- and gamma-secretases cleave on the N- and C-terminal ends respectively. The transmembrane aspartyl protease BACE has been identified as beta-secretase and several proteases (ADAM-10, TACE, PC7) may be alpha-secretases. A number of studies have suggested that presenilins could be gamma-secretases, although this remains to be demonstrated conclusively. Inhibition of beta- and gamma-secretase, or stimulation of alpha-secretase, is a rational strategy for therapeutic intervention in AD.

PMID:
11033346
[Indexed for MEDLINE]
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