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Radiother Oncol. 2000 Oct;57(1):39-43.

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy.

Author information

1
Department of Experimental Clinical Oncology, Danish Cancer Society, Nörrebrogade 44, DK-8000, Aarhus C, Denmark.

Abstract

INTRODUCTION:

In a previous report of 35 patients we suggested that pretreatment tumour pO(2) measured by Eppendorf electrodes was predictive of loco-regional control after primary radiotherapy in advanced head and neck squamous cell carcinomas. Radiother Oncol 41 (1996) 31.

MATERIALS AND METHODS:

The aim of the present study was to test this hypothesis. Therefore, pretreatment tumour pO(2) was measured using the same assay in a new cohort of 35 patients that received an identical treatment being primary radiation along with a total dose of 66-68 Gy as 2 Gy per fraction over 5.5 or 6.5 weeks. Treatment outcome was evaluated as loco-regional control probability at 2 years using the same oxygenation parameter and applying the cut-off value from the first study.

RESULTS:

In agreement with the hypothesis generating study we found that the loco-regional tumour control probability was significantly higher (90%) among well oxygenated tumours as compared with the hypoxic subgroup (45%) (P=0. 04).

CONCLUSION:

This study confirmed that pretreatment tumour oxygenation status was prognostic of loco-regional tumour control after primary radiation alone in advanced head and neck squamous cell carcinoma.

PMID:
11033187
DOI:
10.1016/s0167-8140(00)00223-1
[Indexed for MEDLINE]

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