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Biol Psychiatry. 2000 Oct 1;48(7):702-5.

Lateralized P3 deficit in schizotypal personality disorder.

Author information

1
Harvard Medical School Department of Psychiatry, Brockton/West Roxbury VAMC, Brockton, Massachusetts 02301, USA.

Abstract

BACKGROUND:

Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia and schizotypal personality disorder (SPD). This study was undertaken to determine the replicability of our previous finding of a left-lateralized P3 amplitude deficit in SPD.

METHODS:

We recorded event-related potentials in 21 SPD and 18 normal control subjects in an auditory "oddball" P3 paradigm.

RESULTS:

In the SPD subjects, but not in the control subjects, there was lower P3 amplitude at T3 compared with T4.

CONCLUSIONS:

These results are similar to the ones in our previous work and further support the presence of a left-lateralized P3 deficit in SPD.

PMID:
11032982
PMCID:
PMC2845845
[Indexed for MEDLINE]
Free PMC Article

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