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Science. 2000 Sep 22;289(5487):2066-7.

Biomedicine. Staying slim with insulin in mind.

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  • 1Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98105, USA.


Striking the delicate balance between energy intake in the form of food and energy expenditure in the form of metabolic activity keeps the body extremely busy. As Schwartz explains in his enlightening Perspective, the finding that insulin signals the brain to promote weight loss (BrĂ¼ning et al.) flies in the face of the notion that insulin is involved solely in glucose storage, its conversion to fat, and weight gain.

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