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Breast Cancer. 2000 Jan;7(1):33-6.

Human papillomavirus type 33 DNA in breast cancer in Chinese.

Author information

1
Department of Pathology, Shanghai First People's Hospital, China.

Abstract

BACKGROUND:

The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.

METHODS:

We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.

RESULTS:

DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.

CONCLUSIONS:

Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.

PMID:
11029768
[Indexed for MEDLINE]

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