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Nature. 2000 Sep 28;407(6803):520-3.

A vertebrate globin expressed in the brain.

Author information

1
Institute of Zoology, Johannes Gutenberg University Mainz, Germany. burmeste@mail.uni-mainz.de

Abstract

Haemoglobins and myoglobins constitute related protein families that function in oxygen transport and storage in humans and other vertebrates. Here we report the identification of a third globin type in man and mouse. This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 approximately 2 torr). Analogous to myoglobin, neuroglobin may increase the availability of oxygen to brain tissue. The human neuroglobin gene (NGB), located on chromosome 14q24, has a unique exon-intron structure. Neuroglobin represents a distinct protein family that diverged early in metazoan evolution, probably before the Protostomia/Deuterostomia split.

Comment in

PMID:
11029004
DOI:
10.1038/35035093
[Indexed for MEDLINE]

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