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Neurosci Lett. 2000 Oct 27;293(2):139-42.

Tuberomammillary nucleus activation anticipates feeding under a restricted schedule in rats.

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Departamento de Anatomía, Facultad de Medicina, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile.


We used FOS-immunoreactivity to map changes in the neuronal activity of brain nuclei related to the state of arousal, in rats under a restricted feeding schedule. Our main finding was the outstanding activation of the tuberomammillary nucleus 24h after a meal, and its steep deactivation, which was independent of actually having the meal. The time course of FOS activation and deactivation indicated a burst of tuberomammilary nucleus activity in close temporal relation with the increased locomotor activity shown by rats in anticipation of the next meal.

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