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Vaccine. 2000 Oct 15;19(4-5):538-46.

An immunoglobulin G based chimeric protein induced foot-and-mouth disease specific immune response in swine.

Author information

1
Department of Biology, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong.

Abstract

Epitopes containing the residues 141aa-160aa and 200aa-213aa from foot-and-mouth disease (FMD) serotype O1K HK type FMDV VP1 were joined to a swine immunoglobulin G single heavy chain constant region (scIgG), creating a novel chimeric protein, named F1-scIgG. In this study, inoculation with F1-scIgG induced both FMD virus-neutralizing antibody response and T cell response in swine. Antisera from these F1-scIgG-inoculated swine protected suckling mice against 1000 lethal dose 50 (1000LD(50)) FMD challenge. F1-scIgG-inoculated swine were also fully protected against 50LD(50) FMD virus challenge. The present study demonstrates the clear potential for viral epitopes linked with self-Ig in novel FMD vaccine design.

PMID:
11027819
DOI:
10.1016/s0264-410x(00)00186-9
[Indexed for MEDLINE]

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