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Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11587-92.

Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission.

Author information

1
Takai Biotimer Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, c/o JCR Pharmaceuticals, Kobe 651-2241, Japan.

Abstract

Rab GDP dissociation inhibitor alpha (Rab GDIalpha) is a regulator of the Rab small G proteins implicated in neurotransmission, and mutations of Rab GDIalpha cause human X-linked mental retardation associated with epileptic seizures. In Rab GDIalpha-deficient mice, synaptic potentials in the CA1 region of the hippocampus displayed larger enhancement during repetitive stimulation, which was apparently opposite to the phenotype of Rab3A-deficient mice. Furthermore, the Rab GDIalpha-deficient mice showed hypersensitivity to bicuculline, an inducer of epileptic seizures. These results suggest that Rab GDIalpha plays a specialized role in Rab3A recycling to suppress hyperexcitability via modulation of presynaptic forms of plasticity.

PMID:
11027356
PMCID:
PMC17244
DOI:
10.1073/pnas.97.21.11587
[Indexed for MEDLINE]
Free PMC Article
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