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Ann Neurol. 2000 Oct;48(4):679-84.

Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.

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  • 1Department of Neuroimmunology, Max-Planck-Institute for Neurobiology, Martinsreid, Germany.

Abstract

We demonstrate that HLA-G, a nonclassical major histocompatibility complex class I antigen, is expressed in muscle fibers in various inflammatory myopathies. Further, interferon-gamma induces surface expression and upregulation of mRNA transcripts corresponding to different isoforms of HLA-G in myoblasts cultured from control subjects and patients. HLA-G may have important immunological functions in inflammatory myopathies and other local immune reactions as they occur during vaccination, myoblast transplantation, and gene therapy.

PMID:
11026456
[PubMed - indexed for MEDLINE]
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