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Am J Surg Pathol. 2000 Oct;24(10):1429-32.

Pigmented liver cell adenoma in two male patients.

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Institute of Liver Studies, Guy's King's and St. Thomas' School of Medicine, London, UK.


We report two cases of hepatocyte neoplasia with extensive deposition of Dubin-Johnson-like pigment in men without Dubin-Johnson syndrome. This pigment has previously been described in hepatocellular carcinoma but not in liver cell adenoma. The tumors of both patients showed some atypical cytologic features, but no frank histologic evidence of malignancy. Long-term follow up for several years showed no evidence of recurrence after limited surgical excision. We conclude that tumors with this structure may be cured by limited surgical excision and should be considered as pigmented liver cell adenomas.

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