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Int J Radiat Oncol Biol Phys. 2000 Oct 1;48(3):723-35.

Radiation therapy in T1-T2 glottic carcinoma: influence of various treatment parameters on local control/complications.

Author information

1
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. tmhdir@tmc.ernet.in

Abstract

PURPOSE:

To evaluate the influence of various treatment parameters on local control as well as complications in T1 and T2 glottic carcinomas.

METHODS AND MATERIALS:

Between 1975 and 1989, 676 patients with early glottic carcinoma (460 T1 and 216 T2) received curative radiation with three different treatment regimens, as follows: Regimen 1-50 Gy/15 Fr/3 weeks (3.33 Gy/daily) for 192 patients; Regimen 2-60-62.5 Gy/24-25 Fr/5 weeks (2.5 Gy/daily) for 352 patients; and Regimen 3-55-60 Gy/25-30 Fr/5-6 weeks (2-2.25 Gy/daily) for 132 patients.

RESULTS:

The local control at 10 years was 82% and 57% for T1 and T2 lesions respectively (p = 0.0). For the T1N0M0 group, field size had significant impact on local control with both univariate (p = 0.05) and multivariate (p = 0.03) analysis. For T2N0M0, group field size (p = 0.03) as well as registration year (p = 0.016) were significant in univariate analysis whereas only field size remained significant on multivariate analysis. Persistent radiation edema was noted in 146 (22%) patients and was significantly worse with larger field size (p = 0.000) but not related to different treatment regimens.

CONCLUSION:

The shorter fractionation schedule had comparable local control, without increased complications in comparison to the protracted schedule and is best suited for a busy department.

PMID:
11020569
DOI:
10.1016/s0360-3016(00)00635-0
[Indexed for MEDLINE]

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