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Otolaryngol Head Neck Surg. 2000 Oct;123(4):368-76.

Factors related to outcome of salvage therapy for isolated cervical recurrence of squamous cell carcinoma in the previously treated neck: a multi-institutional study.

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1
Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis 46202-5230, USA.

Abstract

OBJECTIVE:

The goal was to identify factors associated with the outcome of salvage therapy for patients with isolated cervical recurrences of squamous cell carcinoma in the previously treated neck (ICR-PTN).

STUDY DESIGN AND SETTINGS:

A tumor registry search for ICR-PTN patients was performed at 7 participating institutions, and the charts were reviewed. Kaplan-Meier plots for survival and time until re-recurrence were used to evaluate the significance of associated variables.

RESULTS:

Median survival and time until re-recurrence were both 11 months. Survival was better in patients with the following characteristics: nonsurgical initial neck treatment, negative initial disease resection margins, no history of prior recurrence, ipsilateral location of the ICR-PTN relative to the primary, and use of surgical salvage.

CONCLUSIONS:

By pooling the experience of 7 US tertiary care medical centers, we have identified 5 factors that are associated with outcome of salvage therapy for ICR-PTN.

SIGNIFICANCE:

Consideration of these factors, as well as the reviewed literature, should facilitate patient selection for salvage protocols.

PMID:
11020170
DOI:
10.1067/mhn.2000.107680
[Indexed for MEDLINE]
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