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Annu Rev Microbiol. 2000;54:49-79.

Biofilm formation as microbial development.

Author information

1
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. georgeo@Dartmouth.edu

Abstract

Biofilms can be defined as communities of microorganisms attached to a surface. It is clear that microorganisms undergo profound changes during their transition from planktonic (free-swimming) organisms to cells that are part of a complex, surface-attached community. These changes are reflected in the new phenotypic characteristics developed by biofilm bacteria and occur in response to a variety of environmental signals. Recent genetic and molecular approaches used to study bacterial and fungal biofilms have identified genes and regulatory circuits important for initial cell-surface interactions, biofilm maturation, and the return of biofilm microorganisms to a planktonic mode of growth. Studies to date suggest that the planktonic-biofilm transition is a complex and highly regulated process. The results reviewed in this article indicate that the formation of biofilms serves as a new model system for the study of microbial development.

PMID:
11018124
DOI:
10.1146/annurev.micro.54.1.49
[Indexed for MEDLINE]

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