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Nat Immunol. 2000 Oct;1(4):322-8.

The 21- and 23-kD forms of TCR zeta are generated by specific ITAM phosphorylations.

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Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.


The T cell receptor (TCR) zeta subunit contains three immunoreceptor tyrosine-based activation motifs (ITAMs) that translate effective extracellular ligand binding into intracellular signals by becoming phosphorylated into 21- and 23-kD forms. We report here that the 21-kD form of TCR zeta is generated by phosphorylation of the tyrosines in the second and third ITAMs, whereas the 23-kD form is formed by the additional phosphorylation of the membrane-proximal ITAM tyrosines. The stable formation of the 21- and 23-kD species requires the binding of the tandem SH2 domains of ZAP-70. We also report that TCR-mediated signaling processes can proceed independently of either the 21- or 23-kD species of TCR zeta.

[Indexed for MEDLINE]

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