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Bioorg Med Chem Lett. 2000 Oct 2;10(19):2209-12.

Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.

Author information

1
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

Abstract

Piperidine analogues of our previously described piperazine muscarinic antagonists are described. Piperidine analogues show a distinct structure-activity relationship (SAR) that differs from comparable piperazines. Compounds with high selectivity and improved potency for the M2 receptor have been identified. The lead compound, 12b, increases acetylcholine release in vivo. Compounds of this class may be useful for the treatment of cognitive disorders such as Alzheimer's disease (AD).

PMID:
11012031
DOI:
10.1016/s0960-894x(00)00437-6
[Indexed for MEDLINE]

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