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Bioorg Med Chem Lett. 2000 Oct 2;10(19):2171-4.

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.

Author information

1
BASF Bioresearch Corporation, Worcester, MA 01605-5314, USA.

Abstract

Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are novel, potent and selective inhibitors of lck in vitro. Exploration of C-6 position of the pyrrolo[2,3-d]pyrimidine and the terminal phenyl group structure-activity relationship (SAR) is detailed. Compound 1 is orally active in animal models.

PMID:
11012022
DOI:
10.1016/s0960-894x(00)00442-x
[Indexed for MEDLINE]

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