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Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70.

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.

Author information

1
BASF Bioresearch Corporation, Worcester, MA 01605-5314, USA.

Abstract

Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of Ick in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells.

PMID:
11012021
DOI:
10.1016/s0960-894x(00)00441-8
[Indexed for MEDLINE]

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