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Am J Clin Nutr. 2000 Oct;72(4):905-11.

Differential oxidation of individual dietary fatty acids in humans.

Author information

1
Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124, USA. delanyjp@mhs.pbrc.edu

Abstract

BACKGROUND:

Dietary fatty acids that are more prone to oxidation than to storage may be less likely to lead to obesity.

OBJECTIVE:

The aim of this study was to determine the effect of chain length, degree of unsaturation, and stereoisomeric effects of unsaturation on the oxidation of individual fatty acids in normal-weight men.

DESIGN:

Fatty acid oxidation was examined in men consuming a weight-maintenance diet containing 40% of energy as fat. After consuming the diet for 1 wk, subjects were fed fatty acids labeled with (13)C in the methyl or carboxyl position (10 mg/kg body wt). The fatty acids fed in random order were laurate, palmitate, stearate, oleate, elaidate (the trans isomer of oleate), linoleate, and linolenate blended in a hot liquid meal. Breath samples were collected for the next 9 h and the oxidation of each fatty acid was assessed by examining liberated (13)CO(2) in breath.

RESULTS:

Cumulative oxidation over the 9-h test ranged from a high of 41% of the dose for laurate to a low of 13% of the dose for stearate. Of the 18-carbon fatty acids, linolenate was the most highly oxidized and linoleate appeared to be somewhat conserved. (13)C recovery in breath from the methyl-labeled fatty acids was approximately 30% less than that from the carboxyl-labeled fatty acids.

CONCLUSIONS:

In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.

PMID:
11010930
[Indexed for MEDLINE]
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