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Curr Opin Immunol. 2000 Oct;12(5):571-5.

Cytokine-secreting tumor cell vaccines.

Author information

1
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Abstract

Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.

PMID:
11007361
[Indexed for MEDLINE]

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