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Curr Opin Chem Biol. 2000 Oct;4(5):553-8.

Ribonuclease P: a ribonucleoprotein enzyme.

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  • 1Department of Chemistry, University of Michigan, 930 North University, Ann Arbor, MI 27710, USA.


The ribonucleoprotein ribonuclease P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5' end of tRNA. Recent studies have shed light on the structures of RNase-P-RNA-P-protein and RNase-P-RNA-precursor-tRNA complexes, as well as on the positions of catalytic metal ions, emphasizing the importance of the structure to the catalytic function.

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